Can estrogen cream make your face look younger?
Facial estrogen is trending, so let's look at what the research supports. In this video, Dr. Rajani covers:
- How skin changes as estrogen signaling declines during menopause
- Estradiol vs. estriol, and why the difference matters
- Estrogen receptor alpha vs. beta
- Vaginal estrogen cream vs. compounded facial estriol
- What clinical studies show on wrinkles, hydration, elasticity and collagen
- The concentrations used in published studies, and why formulation and dose matter
- Safety considerations, including systemic absorption, increased prolactin in one study, and melasma or pigmentation concerns
- Who should talk with their physician before trying topical estrogen on the face
Clinical Studies:
Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A. Treatment of skin aging with topical estrogens. International Journal of Dermatology. 1996;35(9):669-674.
This is your key study: 59 women, six months, 0.3% estriol vs 0.01% estradiol. Both groups showed improvement in hydration, elasticity/firmness and wrinkle depth; biopsies were performed in a subset. PMID: 8876303. PubMed
PubMed: Schmidt et al. 1996
Creidi P, Faivre B, Agache P, et al. Effect of a conjugated oestrogen (Premarin) cream on ageing facial skin: a comparative study with a placebo cream. Maturitas. 1994;19(3):211-223.
Randomized, double-blind study of 54 women treated for 24 weeks. Conjugated estrogen produced significantly greater improvement in skin thickness and fine wrinkles than placebo. PMID: 7799828. PubMed
PubMed: Creidi et al. 1994
Fuchs KO, Solis O, Tapawan R, Paranjpe J. The effects of an estrogen and glycolic acid cream on the facial skin of postmenopausal women: a randomized histologic study. Cutis. 2003;71(6):481-488.
In 65 women, 0.01% estradiol increased epidermal thickness by approximately 23% after six months; the study also examined glycolic acid and the combination. PMID: 12839261. PubMed
PubMed: Fuchs et al. 2003
Silva LA, Carbonel AAF, Moraes ARB, et al. Collagen concentration on the facial skin of postmenopausal women after topical treatment with estradiol and genistein: a randomized double-blind controlled trial. Gynecological Endocrinology. 2017;33(11):845-848.
A randomized, double-blind study of 30 postmenopausal women found increases in facial type I and III collagen after topical treatment, with the estradiol group outperforming topical genistein. PMID: 28508697. PubMed
PubMed: Silva et al. 2017
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DISCLAIMER: This video does not contain any medical or health related diagnosis or treatment advice. Content provided on this YouTube Channel is for informational purposes only. For any medical or health related advice, please consult with a physician or other healthcare professionals. Further, information about specific products or treatments within this video are not intended to diagnose, treat, cure or prevent disease.
