Skip to content

FREE SHIPPING AVAILABLE ON US ORDERS*

FREE GIFT WITH EVERY ORDER!

SAVE WITH SUBSCRIPTIONS. RESCHEDULE, SKIP, CANCEL AT ANY TIME

  • MUST-HAVES

    PLASMAGLO LED FACE AND JOWL MASK

    RajaniMD Plasma Restore GLO Volufiline cream product image for skin volume and firmness

    PLASMA RESTORE GLO VOLUFILINE CREAM

    RajaniMD retinol A serum product image for anti-aging skincare

    RETINOL A SERUM

    FEATURED
    • MUST-HAVES
    • BEST ROUTINES
    • SUMMER ROUTINES
  • SHOP
    FEATURED
    • BEST SELLERS
    • COURSES
    • FOR MEN
    • K-BEAUTY LINE
    • ESSENTIALS
    • EXTRAS
    • OFFERS
    • SAVE ON SETS
    DEVICES
    • ALL
    • CRYOGLO ROLLER
    • LED GUA SHA
    • LED FACE AND JOWL MASK
    • LED HALO HAIR, FACE AND NECK MASK
    • LED LIGHT THERAPY
    • LED LIP & MOUTH DEVICE
    • MICRO-NEEDLE ROLLER
    • MICRO-NEEDLE COLLECTION
    • NEWA RF AGE REPAIR
    • PEMF TECHNOLOGY
    • PLASMAGLO BOOST VIBRATION
    • PLASMASOMES MICRO-NEEDLE KIT
    • UNDER EYE DUO GLO
    SKINCARE
    • ALL
    • EXFOLIANTS + TONERS
    • KOREAN SKINCARE
    • EYES
    • LIPS
    • LIPO FILLING CREAM
    • MOISTURIZERS
    • NECK
    • NIGHT CREAMS
    • PEEL PADS
    • SERUMS + VIT C
    • SPF SUNSCREEN
    • SPICULE SKINCARE
    WELLNESS
    • ALL
    • 100% BLACK GARLIC
    • COLLAGEN POWDER
    • CREATINE GUMMIES
    • CREATINE MONOHYDRATE POWDER
    • ELECTROGLO ELECTROLYTES
    • KRILL OIL SOFTGELS
    • K2+D3 CAPSULES
    • PLASMA RESTORE GLO GUMMIES
    • SLEEP EXTREME CAPSULES
    • TURMERIC CAPSULES
    • WOMEN'S VITALITY BLEND
    ROUTINE FOR
    • COMPLEXION/PORE SIZE
    • CONTOURING/SCULPTING
    • DARK SPOTS
    • DRY/SENSITIVE SKIN
    • EYES
    • FACIAL FAT LOSS
    • HEALTHY AGING
    • LOWER FACE/JOWLS
    • NECK
    • REDNESS
    • UNEVEN SKIN TONE
    • VERTICAL LIP LINES
  • LEARN
    Meet Dr. Rajani portrait image introducing the founder of RajaniMD beauty and wellness
    RajaniMD doctor’s blog icon image representing skincare articles and expert insights
    EXPLORE
    • OUR PHILOSOPHY
    • GIVING BACK
    • SUSTAINABILITY
    • RAJITV
  • ROUTINES
    RajaniMD skincare routine guide image for step-by-step skincare planning
    RajaniMD skincare routine graphic highlighting 'Start Here' for personalized beauty and wellness recommendations
    ROUTINES
    • SKIN TIPS & TRICKS
    • TIGHTEN YOUR LOOSE SKIN
    • ADDRESS UNDER EYE AGING NOW
  • SKIN QUIZ
Rajani MD Rx Rajani MD clinically proven skincare and aesthetics logo
Login Gift Cards
0
      • MUST-HAVES
      • BEST ROUTINES
      • SUMMER ROUTINES

    PLASMAGLO LED FACE AND JOWL MASK

    RajaniMD Plasma Restore GLO Volufiline cream product image for skin volume and firmness

    PLASMA RESTORE GLO VOLUFILINE CREAM

    RajaniMD retinol A serum product image for anti-aging skincare

    RETINOL A SERUM

      • BEST SELLERS
      • COURSES
      • FOR MEN
      • K-BEAUTY LINE
      • ESSENTIALS
      • EXTRAS
      • OFFERS
      • SAVE ON SETS
      • ALL
      • CRYOGLO ROLLER
      • LED GUA SHA
      • LED FACE AND JOWL MASK
      • LED HALO HAIR, FACE AND NECK MASK
      • LED LIGHT THERAPY
      • LED LIP & MOUTH DEVICE
      • MICRO-NEEDLE ROLLER
      • MICRO-NEEDLE COLLECTION
      • NEWA RF AGE REPAIR
      • PEMF TECHNOLOGY
      • PLASMAGLO BOOST VIBRATION
      • PLASMASOMES MICRO-NEEDLE KIT
      • UNDER EYE DUO GLO
      • ALL
      • EXFOLIANTS + TONERS
      • KOREAN SKINCARE
      • EYES
      • LIPS
      • LIPO FILLING CREAM
      • MOISTURIZERS
      • NECK
      • NIGHT CREAMS
      • PEEL PADS
      • SERUMS + VIT C
      • SPF SUNSCREEN
      • SPICULE SKINCARE
      • ALL
      • 100% BLACK GARLIC
      • COLLAGEN POWDER
      • CREATINE GUMMIES
      • CREATINE MONOHYDRATE POWDER
      • ELECTROGLO ELECTROLYTES
      • KRILL OIL SOFTGELS
      • K2+D3 CAPSULES
      • PLASMA RESTORE GLO GUMMIES
      • SLEEP EXTREME CAPSULES
      • TURMERIC CAPSULES
      • WOMEN'S VITALITY BLEND
      • COMPLEXION/PORE SIZE
      • CONTOURING/SCULPTING
      • DARK SPOTS
      • DRY/SENSITIVE SKIN
      • EYES
      • FACIAL FAT LOSS
      • HEALTHY AGING
      • LOWER FACE/JOWLS
      • NECK
      • REDNESS
      • UNEVEN SKIN TONE
      • VERTICAL LIP LINES
      • OUR PHILOSOPHY
      • GIVING BACK
      • SUSTAINABILITY
      • RAJITV
    Meet Dr. Rajani portrait image introducing the founder of RajaniMD beauty and wellnessRajaniMD doctor’s blog icon image representing skincare articles and expert insights
      • SKIN TIPS & TRICKS
      • TIGHTEN YOUR LOOSE SKIN
      • ADDRESS UNDER EYE AGING NOW
    RajaniMD skincare routine guide image for step-by-step skincare planningRajaniMD skincare routine graphic highlighting 'Start Here' for personalized beauty and wellness recommendations
  • SKIN QUIZ
Account

Cart

Your cart is empty

Start shopping
Retinol A Serum (2%) $159.00
/
  1. Home
  2. Retinol A Serum (2%)
Retinol A Serum (2%)
Retinol A Serum (2%)
Retinol A Serum (2%)
Retinol A Serum (2%)
Rajani MD
4.9
Rated 4.9 out of 5 stars
91 Reviews

Retinol A Serum (2%)

PHYSICIAN-GRADE RENEWAL

FG icon
Step 2: Treat
Moon and stars icon symbol representing nighttime or evening skincare routine
Sale price$159.00
Video Testimonials
Rajani MD
4.9
Rated 4.9 out of 5 stars
91 Reviews
Video Testimonials

Retinol A Serum (2%)

PHYSICIAN-GRADE RENEWAL

FG icon
Step 2: Treat
Moon and stars icon symbol representing nighttime or evening skincare routine
Sale price$159.00
Quantity:

WAYS TO SAVE:

Education/Military/Healthcare – save $15.90. Learn more.

Your Retinol A Serum ::
Powerful Unique Blend of 3 Retinols - Retinaldehyde, Retinol and Retinyl Palmitate with Vitamin C and Avocado Oil

Benefits ::
Visibly Reduces Signs of Aging, Brighten and Rejuvenate Skin
DESCRIPTION
  • Physician strength - 3X retinol strength for maximum anti-aging results
  • Overnight rejuvenation
  • Combines skin antioxidants such as Vitamin C, Vitamin E, and Avocado Oil
  • Quick absorption delivers anti-aging ingredients deep within the skin's surface
  • Free of parabens, fragrance, phthalates, and mineral oil
  • Benefits increase over time, including smoother texture, visible firmness, and reduction of wrinkles and dark spots

Introducing our physician-strength overnight rejuvenation serum, formulated with a powerful blend of 3 retinols - Retinaldehyde, Retinol and Retinyl Palmitate - for maximum anti-aging results. This serum is specially designed to reduce the signs of aging, brighten, and rejuvenate your skin.

Apply before bedtime and wake up to smoother, brighter, and younger-looking skin. Our serum combines skin antioxidants, such as Vitamin C, Vitamin E, and Avocado Oil, to deliver anti-aging ingredients deep within your skin's surface for overnight regeneration. This product is free of parabens, fragrances, phthalates, and mineral oil.

As you continue to use this product, you will see an increase in benefits, including visible firmness and smoothness of skin texture, reduction of wrinkles and dark spots, and added bounce to your skin. This proprietary blend is fragrance-free, paraben-free and dye-free and absorbs quickly and deeply into your skin’s surface layers, leaving you with radiant, youthful-looking skin every morning.

1.01 oz. (30 ml)

HOW TO USE
Home Care:
1. Cleanse your skin to remove dirt, oil, or makeup.
2. Treat your complexion concerns with skin-specific formulas like brightening serums, smoothing eye creams, or hydrating mists.
3. Apply 1-2 pumps of RajaniMD Retinol A Serum.

*Note: Many people skip step 2 and apply it to freshly cleansed skin for the most potent effect. Start by using 1 to 2 times per week and increase frequency as desired or tolerated.


INGREDIENTS
Cyclopentasiloxane, Cyclohexasiloxane, Dimethiconol, Retinyl Palmitate, Oleth-2, Retinaldehyde, Tetrahexyldecyl Ascorbate, Squalane, Persea Gratissima (Avocado) Oil, Tocopheryl Acetate, Retinol, Tocopherol, Dimethicone, Ethylhexyl Cocoate, Glycine Soja (Soybean) Oil, Dimethylmethoxy Chromanol
X

CLINICALLY PROVEN INGREDIENTS

Triple Retinol Complex (Retinaldehyde, Retinol, Retinyl Palmitate): Physician-strength blend for accelerated cell renewal, wrinkle reduction, and visible firming

Vitamin C: Brightens skin tone and supports collagen production for a more radiant complexion

Vitamin E: Powerful antioxidant that protects the skin barrier and enhances skin repair overnight

Avocado Oil: Deeply nourishing, rich in fatty acids to restore softness, elasticity, and hydration

Ultra Moisture
Ultra Moisture
Sale price$129.00
Retinol A Serum (2%)
Retinol A Serum (2%)
Sale price$159.00
Plasma Restore GLO – Volufiline™ Cream
Plasma Restore GLO – Volufiline™ Cream
Sale price$285.00
Developed by Dr. Rajani banner emphasizing medical expertise behind RajaniMD products

DOCTOR'S NOTE

When skin texture softens, tone dulls, and fine lines begin to whisper their presence, it’s a sign that your cellular renewal is lagging. That’s why I formulated this Retinol A Serum — a physician-strength fusion of three retinols (retinaldehyde, retinol and retinyl palmitate) blended with vitamin C and avocado oil, designed to accelerate regeneration, brighten your skin and rebuild your structural glow from within. Use it with intention, protect it with SPF, and watch your skin reflect strength night after night.

- Dr. Rajani

TRUSTED BY 2.4+ MILLION  

Because Results Matter, Dedicated to EDUCATE. EMPOWER. ELEVATE.

PROTECTED SHIPPING AVAILABLE

Free and Expedited Shipping Options. Coverage for Loss, Damage, or Theft.

Customer support

We are here to answer your questions. Contact us at experts@RajaniMD.com.

Secure payment

Your payment information is always processed securely.

FAQs

Retinol A Serum (2%) FAQs

Yes, Dr. Rajani's products are formulated for all skin types, including normal, dry, combination, and oily skin. If you have very sensitive skin or specific skin concerns, we recommend consulting with your physician or contacting our team for personalized guidance.

Our Retinol A Serum is designed to be a great starter retinol because it includes three forms of retinol plus avocado oil for added support. We recommend starting once or twice weekly and increasing gradually as your skin builds tolerance.

Yes, but Retinol Serum and AHA Firming Cream are best used on different days or alternate nights to help reduce irritation. Many people use retinol one night and AHA the next. If your skin is more sensitive, start with each product 1–2 times per week and increase slowly as tolerated. If using either product in the morning, always apply broad-spectrum SPF.

more faqs
4.9
Rated 4.9 out of 5 stars
Based on 91 reviews
5
Rated out of 5 stars
86
4
Rated out of 5 stars
3
3
Rated out of 5 stars
2
2
Rated out of 5 stars
0
1
Rated out of 5 stars
0
98%would recommend this product
Write a Review (Opens in a new window)
91 reviews
  • DD
    Deena D.
    Flag of United States
    Verified Buyer
    Rated 5 out of 5 stars
    19 hours ago
    Clarifying my skin

    I love the effect that this retinol has on my skin. I have no irritation with this formula.

    Was this helpful?
    What is your skin type? Combination
    What is your skin tone? Tan
    What are your skin concerns? Fine Lines and Wrinkles, Collagen Loss, Sun Damage, Jowls and/or Sagging, Neck Concerns, Eye Concerns, Facial Fat Loss
    How old are you? 55-64
    What other Rajani MD products do you use? Devices, Skincare, Supplements
    Product Standouts Fast Acting, Easy To Use, Gentle, Hydrating, Great Ingredients
    RM Profile picture for Rajani MD Beauty and Wellness
    Rajani MD Beauty and Wellness
    25 seconds ago

    This is wonderful to hear, Deena! We love that the Retinol A Serum (2%) has been such a good fit for your skin and skincare routine. Thank you for sharing your experience with us!

  • KB
    Kathie B.
    Flag of United States
    Verified Buyer
    Rated 5 out of 5 stars
    3 days ago
    Dr. Rajani MD has thought of everything... The Retinol A Serum is perfect for me.

    Dr. Rajani MD has thought of everything... The Retinol A Serum is perfect for me. I really enjoy the fact that he advises you to start slow and gives you multiple options on how to use each product and how a product integrates with a protocol that works with your skin and the age of your skin. I learn something new with every YouTube Video that I watch. Dr. Rajani is also focused on bringing the best advances in technology to you at a very reasonable price where the focus is on providing you options to use these technologies safely at home.

    Was this helpful?
    What is your skin type? Normal
    What is your skin tone? Medium
    What are your skin concerns? Jowls and/or Sagging, Sun Damage, Pigmentation, Dark Spots or Melasma, Neck Concerns
    How old are you? 65-74
    What other Rajani MD products do you use? Devices, Skincare
    How long have you used this product 30-60 days
    Product Standouts Great Ingredients, Easy To Use
    RM Profile picture for Rajani MD Beauty and Wellness
    Rajani MD Beauty and Wellness
    2 days ago

    Thank you so much for this thoughtful review, Kathie! We're so glad the Retinol A Serum (2%) has been such a great fit for you, and that Dr. Rajani's approach to building a routine around your skin's needs has resonated with you. It also means a lot to hear you're learning from the YouTube videos, as Dr. Rajani truly believes in making advanced skincare technology accessible and safe to use at home. We’re happy to have you as part of the Rajani MD community!

  • JL
    Joyce L.
    Verified Buyer
    Rated 5 out of 5 stars
    6 days ago
    Retinol serum

    I’m using it every other night !

    And skipping when doing spicule

    Very happy….my skin is looking amazing

    I’m glowing

    Thank you

    Was this helpful?
    What is your skin type? Combination
    What is your skin tone? Medium
    What are your skin concerns? Fine Lines and Wrinkles, Collagen Loss, Jowls and/or Sagging, Neck Concerns, Facial Fat Loss, Eye Concerns
    How old are you? 65-74
    What other Rajani MD products do you use? Devices, Skincare, Supplements
    How long have you used this product 30-60 days
    Product Standouts Easy To Use, Gentle, Hydrating, Great Ingredients, Dramatic Results
  • LD
    Lisa D.
    Verified Buyer
    Rated 5 out of 5 stars
    3 weeks ago
    Best Retinol Serum I Have Ever Used!

    I have sensitive skin and also dry skin since I live in the desert with extremely low humidity. Many retinol products have caused irritation and added additional dryness to my skin. This is the first product I have used that has been gentle on my skin, has caused no dryness, and it delivers excellent results. I get compliments on my skin all the time and I believe this product plays an important role. Thank you for creating such a great product that can benefit even challenging skin types and climates.

    Was this helpful?
    RM Profile picture for Rajani MD Beauty and Wellness
    Rajani MD Beauty and Wellness
    3 weeks ago

    Lisa, thank you for such a thoughtful review! It’s great to hear that our Retinol A Serum (2%) has felt gentle for your sensitive skin, even living somewhere as dry as the desert. We love that you're seeing such wonderful results, and that the people around you are noticing your glow too! Thank you for letting us be part of your skincare routine.

  • DS
    Debbie S.
    Verified Buyer
    Rated 5 out of 5 stars
    1 month ago
    Love it!

    I love this serum and love the way it has improved my skin.

    Was this helpful?
    RM Profile picture for Rajani MD Beauty and Wellness
    Rajani MD Beauty and Wellness
    4 weeks ago

    Debbie, we're so happy to hear that you love your Retinol A Serum and the improvement you've seen in your skin! Thank you so much for sharing your experience with us!

  • MM
    Melissa M.
    Verified Buyer
    Rated 5 out of 5 stars
    1 month ago
    Pleasantly surprised!

    I was a little apprehensive because I have such sensitive and reactive skin, but I followed Nikki’s expert advice and currently am up to 2x/week with no adverse reactions.

    Also seeing a decrease in redness and acne.

    THANK YOU!!

    Was this helpful?
  • CH
    caroline h.
    Verified Buyer
    Rated 5 out of 5 stars
    1 month ago
    favorite retinol

    This has become my favorite go to retinol serum. The formula feels very gently and leaves my skin feeling and looking happy.

    Was this helpful?
  • LR
    leticia r.
    Verified Buyer
    Rated 5 out of 5 stars
    1 month ago
    Smooth Skin

    This Retinol A Serum makes my skin feel smooth and refreshed

    Was this helpful?
    RM Profile picture for Rajani MD Beauty and Wellness
    Rajani MD Beauty and Wellness
    1 month ago

    Thank you, Leticia! We’re so glad the Retinol A Serum 2% leaves your skin feeling smooth and refreshed. Its advanced retinol formula is designed to support a more refined texture and a radiant, youthful-looking complexion with consistent use.

Loading...
Loading...
Show More
Invalid password
Enter

SHOP

  • BEST SELLERS
  • COLLECTIONS
  • OFFERS
  • GIFT CARDS
  • LOCATOR
  • WHOLESALE

SUPPORT

  • CONTACT US
  • SHIPPING + RETURNS
  • HELP CENTER
  • ACCOUNT LOGIN
  • IN THE MEDIA
  • PRESS INQUIRIES

STORE

  • Rx INSIDER REWARDS
  • SUBSCRIBE AND SAVE
  • REFER FRIENDS
  • HSA/FSA ELIGIBILITY
  • WE REWARD HEROES
  • AMBASSADORS
  • OUR PHILOSOPHY
  • SUSTAINABILITY

GIVING BACK

DON'T MISS OUT!

        
Accessibility View
For Your Best Life

© 2026 RAJANI MD. ALL RIGHTS RESERVED. | TERMS | PRIVACY POLICY | EU WITHDRAWAL
The information on this website is not intended to diagnose, treat, cure, or prevent any disease. The content may not be reproduced in any way.

 

Your friend has gifted you a reward!

Your reward!

Claim your Reward for your Ocean Bottle Purchase and Start Making an Impact Today.
Here is your coupon code
Enter your email address to receive your $10 reward.